Cancer immunotherapies utilising intelligent receptor crosstalk
Therapeutic Benefits…
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Boosted Efficacy
When surveying cancer, the TCR instructs the CAR to kill
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Enhanced Safety
When surveying healthy tissue, the TCR instructs the CAR to not kill
… With Relapse Protection
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Protection Against CAR Antigen Dropout
TCR-Mediated Tumor Killing Persists
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Protection Against TCR Antigen Dropout
CAR-Mediated Tumor Killing Persists
Core Team
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Aneesh Aggarwal
CEO & Genomics Lead
MA & MB/BChir - Medicine, University of Cambridge
MScR & DPhil - Ovarian Cancer Genomics, University of Oxford -
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Sooraj Achar
CSO & Immunology Lead
BS - Biochemistry & Math, University of Virginia
DPhil - CAR/TCR Engineering, University of Oxford
Advisory Team
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Michael Dustin
Professor of Molecular Immunology
University of Oxford -
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Paul François
Professor of Biophysics
University of Montreal
High-Impact Publications
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Science, 2022
Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics
Achar*, Bourassa*, Rademaker*…Taylor, François, and Altan-Bonnet
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Blood, 2022
CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR
Shalabi… Achar… Altan-Bonnet, Stroncek, Fry, Taylor, and Shah
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Nature Immunology, 2023
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signalling in response to low-affinity peptides
Gaud, Achar, Bourassa… François, Altan-Bonnet, and Love
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Cell, 2025
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Kondo, Bourassa, Achar… Altan-Bonnet, François, and Taylor
Awards & Recognitions
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Awarded for ‘novel & impactful developments in biology or medicine’
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Awarded to the ‘best paper in cytokine research’
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Awarded for ‘outstanding contributions in the field of medical science that translate fundamental discoveries from the bench to the bedside’
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Awarded to ‘recognise an Oxford researcher who has made an outstanding contribution to immunology, both through their scientific excellence and contributions to the academic community’
Contact Us
Scientist? Investor? Curious? Please get in touch, and we’ll be happy to answer your questions!