Cancer immunotherapies utilising intelligent receptor crosstalk

Therapeutic Benefits…

  • Boosted Efficacy

    When surveying cancer, the TCR instructs the CAR to kill

  • Enhanced Safety

    When surveying healthy tissue, the TCR instructs the CAR to not kill

… With Relapse Protection

  • Decks and Patios icon

    Protection Against CAR Antigen Dropout

    TCR-Mediated Tumor Killing Persists

  • Outdoor Spaces icon

    Protection Against TCR Antigen Dropout

    CAR-Mediated Tumor Killing Persists

Core Team

  • Aneesh Aggarwal

    CEO & Genomics Lead
    MA & MB/BChir - Medicine, University of Cambridge
    MScR & DPhil - Ovarian Cancer Genomics, University of Oxford

  • Sooraj Achar

    CSO & Immunology Lead
    BS - Biochemistry & Math, University of Virginia
    DPhil - CAR/TCR Engineering, University of Oxford

Advisory Team

  • Michael Dustin

    Professor of Molecular Immunology
    University of Oxford

  • Paul François

    Professor of Biophysics
    University of Montreal

High-Impact Publications

  • Science, 2022

    Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics

    Achar*, Bourassa*, Rademaker*…Taylor, François, and Altan-Bonnet

  • Blood, 2022

    CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

    Shalabi… Achar… Altan-Bonnet, Stroncek, Fry, Taylor, and Shah

  • Nature Immunology, 2023

    CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signalling in response to low-affinity peptides

    Gaud, Achar, Bourassa… François, Altan-Bonnet, and Love

  • Cell, 2025

    Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

    Kondo, Bourassa, Achar… Altan-Bonnet, François, and Taylor

Awards & Recognitions

  • Awarded for ‘novel & impactful developments in biology or medicine’

  • Awarded to the ‘best paper in cytokine research’

  • Awarded for ‘outstanding contributions in the field of medical science that translate fundamental discoveries from the bench to the bedside’

  • Awarded to ‘recognise an Oxford researcher who has made an outstanding contribution to immunology, both through their scientific excellence and contributions to the academic community’

Contact Us

Scientist? Investor? Curious? Please get in touch, and we’ll be happy to answer your questions!